.

Department of Pathology, Microbiology, and Immunology

 

 

Lan Wu, M.D.

 

 

Research Associate Professor

Dept of Pathology, Microbiology and Immunology

 

 

Contact Information

 

 

Office Location:
AA5206, MCN
Phone: 615-343-2708
E-mail:  lan.wu.1@vanderbilt.edu

 

Campus Mail address:

Pathology, Microbiology and Immunology-5th Fl

A-5301 MCN (2363)

 

US Mailing address:
Vanderbilt University School of Medicine

Pathology, Microbiology, and Immunology-5th Fl

MCN A-5301
Nashville, TN 37232-2363

 

 

 

Education

 

 

M.D., Tongji Medicial University


 

 

Publications

 

 

Wu, L, Van Kaer, L. Natural killer T cells and autoimmune disease. Curr Mol Med, 9(1), 4-14, 2009

Wu, L, Gabriel, CL, Parekh, VV, Van Kaer, L. Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities. Tissue Antigens, 73(6), 535-45, 2009

Parekh, VV, Lalani, S, Kim, S, Halder, R, Azuma, M, Yagita, H, Kumar, V, Wu, L, Kaer, LV. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J Immunol, 182(5), 2816-26, 2009

Kim, S, Lalani, S, Parekh, VV, Wu, L, Van Kaer, L. Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants. Expert Rev Vaccines, 7(10), 1519-32, 2008

Kim, S, Lalani, S, Parekh, VV, Vincent, TL, Wu, L, Van Kaer, L. Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J Clin Invest, 118(6), 2301-15, 2008

Wu, L, Van Kaer, L. Role of NKT cells in the digestive system. II. NKT cells and diabetes. Am J Physiol Gastrointest Liver Physiol, 293(5), G919-22, 2007

Parekh, VV, Wilson, MT, Olivares-Villag??mez, D, Singh, AK, Wu, L, Wang, CR, Joyce, S, Van Kaer, L. Glycolipid antigen induces long-term natural killer T cell anergy in mice. J Clin Invest, 115(9), 2572-83, 2005

Wu, L, Nicholson, W, Knobel, SM, Steffner, RJ, May, JM, Piston, DW, Powers, AC. Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines. J Biol Chem, 279(13), 12126-34, 2004

Steffner, RJ, Wu, L, Powers, AC, May, JM. Ascorbic acid recycling by cultured beta cells: effects of increased glucose metabolism. Free Radic Biol Med, 37(10), 1612-21, 2004

Parekh, VV, Singh, AK, Wilson, MT, Olivares-Villag??mez, D, Bezbradica, JS, Inazawa, H, Ehara, H, Sakai, T, Serizawa, I, Wu, L, Wang, CR, Joyce, S, Van Kaer, L. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J Immunol, 173(6), 3693-706, 2004

Wu, L, Nicholson, W, Wu, CY, Xu, M, McGaha, A, Shiota, M, Powers, AC. Engineering physiologically regulated insulin secretion in non-beta cells by expressing glucagon-like peptide 1 receptor. Gene Ther, 10(19), 1712-20, 2003

Hong, S, Wilson, MT, Serizawa, I, Wu, L, Singh, N, Naidenko, OV, Miura, T, Haba, T, Scherer, DC, Wei, J, Kronenberg, M, Koezuka, Y, Van Kaer, L. The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med, 7(9), 1052-6, 2001

Wu, L, Fritz, JD, Powers, AC. Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity. Endocrinology, 139(10), 4205-12, 1998

Fritz, JD, Utz, AL, Hale, NM, Wu, L, Powers, AC, Verdoorn, TA, Robertson, D. Gene-based neurotransmitter modulation in cerebellar granule neurons. J Neurochem, 68(1), 204-12, 1997

Buchs, A, Wu, L, Morita, H, Whitesell, RR, Powers, AC. Two regions of GLUT 2 glucose transporter protein are responsible for its distinctive affinity for glucose. Endocrinology, 136(10), 4224-30, 1995

Morita, H, Yano, Y, Niswender, KD, May, JM, Whitesell, RR, Wu, L, Printz, RL, Granner, DK, Magnuson, MA, Powers, AC. Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. J Clin Invest, 94(4), 1373-82, 1994