Kyra Richter, Ph.D.
Research Assistant Professor
Dept. of Pathology, Microbiology and Immunology
Pathology, Microbiology and Immunology-5th Fl
MCN A-5301 (2363)
Vanderbilt University School of Medicine
Department of Pathology, Microbiology and Immunology-5th Fl
1161 21st Ave. S.
Nashville, TN 37232-2363
human immunology, T lymphocytes, infectious disease, sarcoidosis, granulomatous inflammation
The focus of my research is to study the role of the adaptive immune system in disease pathogenesis and to clearly define the mechanisms that regulate pathogenesis. By dissecting the host-cell interactions in granulomatous inflammation, I hope to identify host factors that may be exploited for novel therapies in chronic lung disease. Moreover, by investigating the role of individual cell subsets in granulomatous formation and maintenance, I hope to gain insight into how granulomatous inflammation is initiated and progresses to chronicity.
Oswald-Richter, K, Sato, H, Hajizadeh, R, Shepherd, BE, Sidney, J, Sette, A, Newman, LS, Drake, WP. Mycobacterial ESAT-6 and katG are Recognized by Sarcoidosis CD4+ T Cells When Presented by the American Sarcoidosis Susceptibility Allele, DRB1*1101. J Clin Immunol, 30(1), 157-66, 2010
Oswald-Richter, KA, Culver, DA, Hawkins, C, Hajizadeh, R, Abraham, S, Shepherd, BE, Jenkins, CA, Judson, MA, Drake, WP. Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosis. Infect Immun, 77(9), 3740-8, 2009
Antons, AK, Wang, R, Oswald-Richter, K, Tseng, M, Arendt, CW, Kalams, SA, Unutmaz, D. Naive precursors of human regulatory T cells require FoxP3 for suppression and are susceptible to HIV infection. J Immunol, 180(2), 764-73, 2008
Oswald-Richter, K, Grill, SM, Leelawong, M, Tseng, M, Kalams, SA, Hulgan, T, Haas, DW, Unutmaz, D. Identification of a CCR5-expressing T cell subset that is resistant to R5-tropic HIV infection. PLoS Pathog, 3(4), e58, 2007
Carlisle, J, Evans, W, Hajizadeh, R, Nadaf, M, Shepherd, B, Ott, RD, Richter, K, Drake, W. Multiple Mycobacterium antigens induce interferon-gamma production from sarcoidosis peripheral blood mononuclear cells. Clin Exp Immunol, 150(3), 460-8, 2007
Dillon, S, Agrawal, S, Banerjee, K, Letterio, J, Denning, TL, Oswald-Richter, K, Kasprowicz, DJ, Kellar, K, Pare, J, van Dyke, T, Ziegler, S, Unutmaz, D, Pulendran, B. Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest, 116(4), 916-28, 2006
Oswald-Richter, K, Torres, VJ, Sundrud, MS, VanCompernolle, SE, Cover, TL, Unutmaz, D. Helicobacter pylori VacA toxin inhibits human immunodeficiency virus infection of primary human T cells. J Virol, 80(23), 11767-75, 2006
VanCompernolle, SE, Taylor, RJ, Oswald-Richter, K, Jiang, J, Youree, BE, Bowie, JH, Tyler, MJ, Conlon, JM, Wade, D, Aiken, C, Dermody, TS, KewalRamani, VN, Rollins-Smith, LA, Unutmaz, D. Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells. J Virol, 79(18), 11598-606, 2005
Oswald-Richter, K, Grill, SM, Shariat, N, Leelawong, M, Sundrud, MS, Haas, DW, Unutmaz, D. HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol, 2(7), E198, 2004