Department of Pathology, Microbiology, and Immunology



Mohamed Mokhtar Desouki, M.D., Ph.D.



Assistant Professor

Dept. of Pathology, Microbiology and Immunology



Contact Information



Office Location:
MCN C-2310A

Phone: 615-343-9540
: mohamed.desouki@vanderbilt.edu


Campus Mail address:

Pathology, Microbiology and Immunology-3rd Fl

MCN C-3321 (2561)


US Mailing address:
Vanderbilt University School of Medicine
Dept of Pathology, Microbiology and Immunology-3rd Fl
MCN C-3321

Nashville, TN 37232-2561






MBBCh, Faculty of Medicine, Cairo University, Egypt
Master and Doctorate (PhD), Faculty of Medicine, Cairo University, Egypt
AP Fellowship, MUSC, Charleston, SC, USA
Breast/Gyn Fellowship, UPMC, Pittsburgh, PA, USA
Ap/CP Pathology Residency, MUSC, Charleston, SC, USA



Research Keywords



Cancer Breast, Gynecologic Pathology, Prostate Cancer



Research Description








Desouki, MM, Fadare, O, Kanbour, A, Kanbour-Shakir, A. Immunophenotype and K-RAS mutation in mucinous ovarian adenocarcinoma with mural nodule of high-grade sarcoma: case report. Int J Gynecol Pathol, 33(2), 186-90, 2014

Fadare, O, Desouki, MM, Gwin, K, Hanley, KZ, Jarboe, EA, Liang, SX, Quick, CM, Zheng, W, Parkash, V, Hecht, JL. Frequent expression of napsin A in clear cell carcinoma of the endometrium: potential diagnostic utility. Am J Surg Pathol, 38(2), 189-96, 2014

Hameed, O, Wei, S, Desouki, MM, Umphrey, H. Breast Cancer: Advances in Surgical Pathology. Series editor Philip T. Cagle and Timothy C Allen. Publisher: Lippincott Williams & Wilkins. ISBN-10: 1451191715., 2014

Khoury, T, Karabakhtsian, RG, Mattson, D, Yan, L, Syriac, S, Habib, F, Liu, S, Desouki, MM. Pleomorphic lobular carcinoma in??situ of the breast: clinicopathological review of 47 cases. Histopathology, 64(7), 981-93, 2014

Desouki, MM, Doubinskaia, I, Gius, D, Abdulkadir, SA. Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer. Hum Pathol, 45(5), 1071-7, 2014

Li, Z, Fadare, O, Hameed, O, Zhao, C, Desouki, MM. Incidental atypical proliferative lesions in reduction mammoplasty specimens in patients with a history of breast cancer. Hum Pathol, 45(1), 104-9, 2014

Desouki, MM, Kallas, SJ, Khabele, D, Crispens, MA, Hameed, O, Fadare, O. Differential vimentin expression in ovarian and uterine corpus endometrioid adenocarcinomas: diagnostic utility in distinguishing double primaries from metastatic tumors. Int J Gynecol Pathol, 33(3), 274-81, 2014

Mohamed, SA, Atta, IS, Rowan, BG, Desouki, MM. ER?? and ERK1/2 MAP kinase expression in microdissected stromal and epithelial endometrial cells. J Egypt Natl Canc Inst, 26(1), 37-41, 2014

Fadare, O, Gwin, K, Desouki, MM, Crispens, MA, Jones, HW, Khabele, D, Liang, SX, Zheng, W, Mohammed, K, Hecht, JL, Parkash, V. The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium. Mod Pathol, 2013

Fadare, O, Liang, SX, Crispens, MA, Jones, HW, Khabele, D, Gwin, K, Zheng, W, Mohammed, K, Parkash, V, Hecht, JL, Desouki, MM. Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance. Hum Pathol, 44(8), 1508-15, 2013

Rawish, KR, Desouki, MM, Crispens, MA, Fadare, O. Conventional endometrioid adenocarcinomas of the endometrium recurring as clear cell tumors: comparative immunohistochemical analyses. Ann Diagn Pathol, 17(3), 270-5, 2013

Fadare, O, Zheng, W, Crispens, MA, Jones, HW, Khabele, D, Gwin, K, Liang, SX, Mohammed, K, Desouki, MM, Parkash, V, Hecht, JL. Morphologic and other clinicopathologic features of endometrial clear cell carcinoma: a comprehensive analysis of 50 rigorously classified cases. Am J Cancer Res, 3(1), 70-95, 2013

Fadare, O, Parkash, V, Gwin, K, Hanley, KZ, Jarboe, EA, Liang, SX, Quick, CM, Zheng, W, Rawish, KR, Hecht, JL, Desouki, MM. Utility of ??-methylacyl-coenzyme-A racemase (p504s) immunohistochemistry in distinguishing endometrial clear cell carcinomas from serous and endometrioid carcinomas. Hum Pathol, 44(12), 2814-21, 2013

Desouki, MM, Lioyd, J, Xu, H, Cao, D, Barner, R, Zhao, C. CDX2 may be a useful marker to distinguish primary ovarian carcinoid from gastrointestinal metastatic carcinoids to the ovary. Hum Pathol, 44(11), 2536-41, 2013

Desouki, MM, Li, Z, Hameed, O, Fadare, O, Zhao, C. Incidental atypical proliferative lesions in reduction mammoplasty specimens: analysis of 2498 cases from 2 tertiary women''s health centers. Hum Pathol, 2013

Gonzalez, RS, Chamberlain, BK, Giannico, G, Fadare, O, Crispens, MA, Khabele, D, Desouki, MM . Ovarian Serous Borderline Tumor Identified in Endometrial Biopsy: A Case Report.. Gynecology & Obstetrics, 179(3:), 2013

Fadare, O, James, S, Desouki, MM, Khabele, D. Coordinate patterns of estrogen receptor, progesterone receptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrial serous adenocarcinomas. Ann Diagn Pathol, 2013

Franklin, RB, Levy, BA, Zou, J, Hanna, N, Desouki, MM, Bagasra, O, Johnson, LA, Costello, LC. ZIP14 zinc transporter downregulation and zinc depletion in the development and progression of hepatocellular cancer. J Gastrointest Cancer, 43(2), 249-57, 2012

Li, X, Weaver, O, Desouki, MM, Dabbs, D, Shyum, S, Carter, G, Zhao, C. Microcalcification is an important factor in the management of breast intraductal papillomas diagnosed on core biopsy. Am J Clin Pathol, 138(6), 789-95, 2012

Hinshaw, HD, Smith, AL, Desouki, MM, Olawaiye, AB. Malignant transformation of a mature cystic ovarian teratoma into thyroid carcinoma, mucinous adenocarcinoma, and strumal carcinoid: a case report and literature review. Case Rep Obstet Gynecol, 2012, 269489, 2012

Scott, EM, Smith, AL, Desouki, MM, Olawaiye, AB. Epithelioid trophoblastic tumor: a case report and review of the literature. Case Rep Obstet Gynecol, 2012, 862472, 2012

Zhang, XS, Dong, HY, Zhang, LL, Desouki, MM, Zhao, C. Xanthogranulomatous inflammation of the female genital tract: report of three cases. J Cancer, 3, 100-6, 2012

Costello, LC, Zou, J, Desouki, MM, Franklin, RB. Evidence for Changes in RREB-1, ZIP3, and Zinc in the Early Development of Pancreatic Adenocarcinoma. J Gastrointest Cancer, 2012

Zhao, C, Desouki, MM, Florea, A, Mohammed, K, Li, X, Dabbs, D. Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification. Am J Clin Pathol, 138(1), 72-8, 2012

Liao, S, Desouki, MM, Gaile, DP, Shepherd, L, Nowak, NJ, Conroy, J, Barry, WT, Geradts, J. Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast. Genes Chromosomes Cancer, 2012

Costello, LC, Levy, BA, Desouki, MM, Zou, J, Bagasra, O, Johnson, LA, Hanna, N, Franklin, RB. Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma. Cancer Biol Ther, 12(4), 297-303, 2011

Desouki, MM, Liao, S, Huang, H, Conroy, J, Nowak, NJ, Shepherd, L, Gaile, DP, Geradts, J. Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach. J Cancer Res Clin Oncol, 137(5), 795-809, 2011

Owens, KM, Kulawiec, M, Desouki, MM, Vanniarajan, A, Singh, KK. Impaired OXPHOS complex III in breast cancer. PLoS One, 6(8), e23846, 2011

Ayyasamy, V, Owens, KM, Desouki, MM, Liang, P, Bakin, A, Thangaraj, K, Buchsbaum, DJ, LoBuglio, AF, Singh, KK. Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PLoS One, 6(9), e24792, 2011

Zou, J, Milon, BC, Desouki, MM, Costello, LC, Franklin, RB. hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1). Prostate, 2011

Desouki, MM. Uterus online surgical pathology Topics., 2011

Turner, DP, Findlay, VJ, Moussa, O, Semenchenko, VI, Watson, PM, LaRue, AC, Desouki, MM, Fraig, M, Watson, DK. Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression. Prostate, 71(16), 1723-35, 2011

Chou, PC, Shunmugavel, A, El Sayed, H, Desouki, MM, Nguyen, SA, Khan, M, Singh, I, Bilgen, M. Preclinical use of longitudinal MRI for screening the efficacy of S-nitrosoglutathione in treating spinal cord injury. J Magn Reson Imaging, 33(6), 1301-11, 2011

Desouki, MM, Liao, S, Conroy, J, Nowak, NJ, Shepherd, L, Gaile, DP, Geradts, J. The genomic relationship between primary breast carcinomas and their nodal metastases. Cancer Invest, 29(4), 300-7, 2011

Abedalthagafi, M, Rushing, EJ, Auerbach, A, Desouki, MM, Marwaha, J, Wang, Z, Fanburg-Smith, JC. Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases. Ann Diagn Pathol, 14(1), 15-22, 2010

Desouki MM, Adams B, Maria-Medina A, Costa JL, Lazarchick J . Immunodefficiency-associated lymphoproliferative disease of the Hodgkin lymphoma-like variant treated with Rituximab: Case report. XV Meeting of the European association of hematopathology, Uppsala, Sweden., 2010

Graham, KA, Kulawiec, M, Owens, KM, Li, X, Desouki, MM, Chandra, D, Singh, KK. NADPH oxidase 4 is an oncoprotein localized to mitochondria. Cancer Biol Ther, 10(3), 223-31, 2010

Desouki, MM, Post, GR, Cherry, D, Lazarchick, J. PAX-5: a valuable immunohistochemical marker in the differential diagnosis of lymphoid neoplasms. Clin Med Res, 8(2), 84-8, 2010

Tatar, I, Chou, PC, Desouki, MM, El Sayed, H, Bilgen, M. Evaluating regional blood spinal cord barrier dysfunction following spinal cord injury using longitudinal dynamic contrast-enhanced MRI. BMC Med Imaging, 9, 10, 2009

Moussa, O, Turner, DP, Feldman, RJ, Sementchenko, VI, McCarragher, BD, Desouki, MM, Fraig, M, Watson, DK. PDEF is a negative regulator of colon cancer cell growth and migration. J Cell Biochem, 108(6), 1389-98, 2009

Kulawiec, M, Safina, A, Desouki, MM, Still, I, Matsui, S, Bakin, A, Singh, KK. Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion. Cancer Biol Ther, 7(11), 1732-43, 2008

Sood, AK, Saxena, R, Groth, J, Desouki, MM, Cheewakriangkrai, C, Rodabaugh, KJ, Kasyapa, CS, Geradts, J. Expression characteristics of prostate-derived Ets factor support a role in breast and prostate cancer progression. Hum Pathol, 38(11), 1628-38, 2007

Singh, KK, Desouki, MM, Franklin, RB, Costello, LC. Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues. Mol Cancer, 5, 14, 2006

Kulawiec, M, Arnouk, H, Desouki, MM, Kazim, L, Still, I, Singh, KK. Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer. Cancer Biol Ther, 5(8), 967-75, 2006

Desouki, MM, Kulawiec, M, Bansal, S, Das, GM, Singh, KK. Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors. Cancer Biol Ther, 4(12), 1367-73, 2005

Singh, KK, Kulawiec, M, Still, I, Desouki, MM, Geradts, J, Matsui, S. Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. Gene, 354, 140-6, 2005

Franklin, RB, Feng, P, Milon, B, Desouki, MM, Singh, KK, Kajdacsy-Balla, A, Bagasra, O, Costello, LC. hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. Mol Cancer, 4, 32, 2005

Kershah, SM, Desouki, MM, Koterba, KL, Rowan, BG. Expression of estrogen receptor coregulators in normal and malignant human endometrium. Gynecol Oncol, 92(1), 304-13, 2004

Desouki, MM, Rowan, BG. SRC kinase and mitogen-activated protein kinases in the progression from normal to malignant endometrium. Clin Cancer Res, 10(2), 546-55, 2004