Research Round-up

From the Summer 2016 edition of Vanderbilt Medicine Magazine

Immune defenses in asthma Patients with asthma are at increased risk for invasive bacterial infections and bacterial pneumonia, but the mechanisms that impair their immune system defenses against pathogens are unknown. Melissa Bloodworth, R. Stokes Peebles, Jr., M.D., and colleagues … Continued


From the Winter 2016 edition of Vanderbilt Medicine Magazine

Compound developed at VUMC may delay Huntington’s disease  A compound developed by researchers at Vanderbilt University can improve early symptoms and delay progression of Huntington’s disease in a mouse model of the neurodegenerative disorder. The findings, reported in the Proceedings of … Continued


From the Summer 2015 edition of Vanderbilt Medicine Magazine

Antibiotics with anticancer potential The type II topoisomerases—enzymes that manage tangles and supercoils in DNA—exist in all organisms and are important drug targets. Widely prescribed anticancer agents including etoposide and doxorubicin target human type II topoisomerases, and quinolone antibiotics such as ciprofloxacin target … Continued