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Pax8-rtTA - Renal specific transgenic database

Common name Pax8-rtTA
Mouse strain C57BL/6
Genebank listing: PAX8 (18510)
Source Robert Koesters (email)
Renal cell types Connecting Tubule,Principal cells (collecting duct),Intercalated cells Type A (collecting duct),Intercalated cells Type B (collecting duct),Intercalated cells Type non-A/N (collecting duct),Proximal tubule S1 segment,Proximal tubule S2 segment,Proximal tubule S3 segment,Thin limb Ascending (Loop of Henle),Thin limb Descending (Loop of Henle),Thick Limb (Loop of Henle),Macula Densa (Thick Ascending Limb),Distal convoluted tubule,Proximal tubule
Extent of expression/recombination in renal target cells Virtually complete nephron-wide, exclusive of glomerulus, activity when doxycycline is given to the adult.
Other cell types some periportal hepatocytes when doxycycline is given to the adult. Extensively expressed throughout body when given during embryogenesis.
Applications nephron-wide gene activation or knockout
Image (click to zoom) None provided
  • Traykova-Brauch M, Schonig K, Greiner O, Miloud T, Jauch A, Bode M, Felsher DW, Glick AB, Kwiatkowski DJ, Bujard H, Horst J, von Knebel Doeberitz M, Niggli FK, Kriz W, Grone HJ, Koesters R. An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med (2008) 14:979-84 View in PubMed

Availability Yes
Available states Breeding pairs
Available at (source) Jackson Labs. Strain ID: 007176
Added on/by 2010-01-20 / Donald Kohan
Modified on/by 2010-03-01 / Donald Kohan