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Ksp-cadherin-CreERT2 - Renal specific transgenic database

Common name Ksp-cadherin-CreERT2
Mouse strain Other
Genebank listing: CDH16 (12556)
Source Dorien J. M. Peters (email)
Renal cell types Connecting Tubule,Principal cells (collecting duct),Proximal tubule S1 segment,Proximal tubule S2 segment,Proximal tubule S3 segment,Thick Limb (Loop of Henle),Distal convoluted tubule,Proximal tubule
Extent of expression/recombination in renal target cells Expressed in a mosaic pattern mainly in thick limb through collecting duct, but some also in proximal tubule. May be expressed in intercalated cells, but non specifically examined.
Other cell types None
Applications Nephron-specific gene targeting
Image (click to zoom) None provided
  • Lantinga-van Leeuwen IS, Leonhard WN, van der Wal A, Breuning MH, de Heer E, Peters DJ. Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet (2007) 16:3188-96 View in PubMed

  • Lantinga-van Leeuwen IS, Leonhard WN, van de Wal A, Breuning MH, Verbeek S, de Heer E, Peters DJ. Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells. Genesis (2006) 44:225-32 View in PubMed

Availability Unknown
Added on/by 2010-01-20 / Donald Kohan
Modified on/by 2010-03-01 / Donald Kohan